HRID2255040

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2723790

Thiourea

CH4N2S

结构：COc1cc2c(cc1OC)C(c1ccccc1)N(C(=O)CCl)CC2

HCID3789195

2-Chloro-1-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

C19H20ClNO3

PRODUCTS

生成物

HCID151186

6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

C17H19NO2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Heat a mixture of thiourea (45 mg), the product of step B and etanol (8 mL) at reflux for 3 h. Remove the solvent in vacuo, dissolve the residue in chloroform and filter. Concentrate the filtrate to give 153 mg of the title compound. 1H NMR (CDCl3); δ 7.4-7.18 (5 H, m); 6.63 (1 H, s); 6.24 (1 H, s); 5.03 (1 H, s); 3.85 (3 H, s); 3.61 (3 H, s); 3.28-2.65 (4 H, m); 2.3 (1 H, br. s).

WORKUP

后处理

temperatureHeat
customRemove the solvent in vacuo
dissolutiondissolve the residue in chloroform
filtrationfilter
concentrationConcentrate the filtrate