Thiourea → 6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Participants

Role	Name	HCID	Charge
Reactant	Thiourea	HCID 2723790	—
Reactant	2-Chloro-1-(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone	HCID 3789195	—
Solvent	Ethanol	HCID 702	—
Product	6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline	HCID 151186	—

Reaction Steps

Heat a mixture of thiourea (45 mg), the product of step B and etanol (8 mL) at reflux for 3 h. Remove the solvent in vacuo, dissolve the residue in chloroform and filter. Concentrate the filtrate to give 153 mg of the title compound. 1H NMR (CDCl3); δ 7.4-7.18 (5 H, m); 6.63 (1 H, s); 6.24 (1 H, s); 5.03 (1 H, s); 3.85 (3 H, s); 3.61 (3 H, s); 3.28-2.65 (4 H, m); 2.3 (1 H, br. s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05238935
Source dataset	uspto-grants-1993_08
ORD ID	ord-c8bbf864824d4b4ea33fe5f843ae36de
Source note	uspto-grants-1993_08