3-Formylbenzamidine hydrochloride → HCID 178478849, compound

HRID 2255056Notes

Reaction equation

HRID 2255056 reaction equation
C1(C)C(S(O)(=O)=O)=CC=CC=1.[NH2:12][NH:13][C:14]([NH:16][OH:17])=[NH:15].[ClH:18].[CH:19]([C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24]([NH2:26])=[NH:25])=O>O.Cl.CO>[ClH:18].[ClH:18].[OH:17][NH:16][C:14]([NH:13][N:12]=[CH:19][C:21]1[CH:29]=[CH:28][CH:27]=[C:23]([C:24](=[NH:25])[NH2:26])[CH:22]=1)=[NH:15]

Participants

6

Reactant 2

HCID 27592083-Formylbenzamidine hydrochlorideHCID 178424425HCID 178424425, compound

Product 1

HCID 178478849HCID 178478849, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 7.3 g (0.028 mol) of 1-amino-3-hydroxyguanidine toluene-sulfonate in 14 ml of water and 14.5 ml of 2N hydrochloric acid is added to a solution of 6.9 g (0.028 mol) of crude 3-formylbenzamidine hydrochloride (prepared as described in Example 1b) in 28 ml of methanol, and the reaction mixture is heated at 70° for 1 hour. It is then cooled and concentrated by evaporation, and the crude product is recrystallised from water/ethanol; m.p. 248°-250°.

Workup

  1. temperaturethe reaction mixture is heated at 70° for 1 hour
  2. temperatureIt is then cooled
  3. concentrationconcentrated by evaporation
  4. customthe crude product is recrystallised from water/ethanol

Sources & evidence

ORD record
ord-51aa034ab792416c8bf4948af4618e0a
Source dataset
uspto-grants-1993_08
Patent number
US05238941

Reaction notes

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