2,5-Pyridinedicarboxylic acid → HCID 14210555, compound

HRID 2255071Notes

Reaction equation

HRID 2255071 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([OH:12])=[O:11].[C:13]([O:23][CH3:24])(=[O:22])[CH:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)O>>[N:1]1[CH:6]=[C:5]([C:7]([O:9][CH:14]([C:13]([O:23][CH3:24])=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH:14]([C:13]([O:23][CH3:24])=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:11]

Participants

3

Reactant 2

HCID 74932,5-Pyridinedicarboxylic acidHCID 78066(+-)-Methyl mandelate

Product 1

HCID 14210555HCID 14210555, compound

Procedure

Analogously to Example 1, 10 g of pyridine-2,5-dicarboxylic acid are converted into the acid chloride and this is reacted with 19.9 g of methyl (±)-mandelate. After extraction, working up is carried out by chromatography over silica gel with a mixture of toluene and ethyl acetate as the mobile phase.

Workup

  1. extractionAfter extraction
  2. additionworking up is carried out by chromatography over silica gel with a mixture of toluene and ethyl acetate as the mobile phase

Sources & evidence

ORD record
ord-b209a4f0d1d64f799bd0058062354069
Source dataset
uspto-grants-1993_08
Patent number
US05238948

Reaction notes

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