p-Fluoronitrobenzene → HCID 12874832, compound

HRID 2255081Notes

Reaction equation

HRID 2255081 reaction equation
[CH3:1][N:2]([CH3:13])[CH2:3][CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[OH:6].F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1>>[CH3:13][N:2]([CH3:1])[CH2:3][CH2:4][CH:5]([O:6][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 1106653-(Dimethylamino)-1-phenylpropan-1-ol

Product 1

HCID 12874832HCID 12874832, compoundYield 88.5%

Procedure

Following the procedure of Example 3, 17.9 g of 3-dimethylamino-1-phenyl-1-propanol and 14.1 g of 1-fluoro-4-nitrobenzene were reacted to provide 26.54 g of the subtitle intermediate as a red oil. Preparation of the oxalate salt of a small portion of the oil provided yellow crystals with a melting point of 155°-157° C. (with decomposition).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-96f7f12ce73e463cae938e5b26dcfd07
Source dataset
uspto-grants-1993_08
Patent number
US05238959

Reaction notes

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