Ethylenediamine → HCID 19741758, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 7, 11.8 g (0.08 mol) of 4-cyanobenzoic acid are reacted with triethylamine and ethyl chloroformate and worked-up and then added dropwise to a solution of 21.4 ml of ethylenediamine in 350 ml of chloroform. After adding 45 ml of dimethylformamide, the mixture is heated to 60° for a further 1 hour. After filtration, the filtrate is concentrated, and the residue is treated in the same manner as described in Example 7. There are obtained 3.5 g of N-(2-aminoethyl)-4-cyanobenzamide hydrochloride, m.p. 212°-215° (decomposition). The free base melts at 124°-126°.

Provenance & Evidence