HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 23179855, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Product | HCID 23179855 | HCID 23179855 | 82% |
Reaction Steps
A mixture of 54 g of 1-(4-fluorophenyl)ethanone, 39,1 g of dimethylamine hydrochloride, 14,4 g of paraformaldehyde, and 10 ml of 36% hydrochloric acid was refluxed for 2 h in 500 ml of ethanol. The ethanol was evaporated and ethyl acetate was added, after which 79 g (82%) of 1-(4-fluorophenyl)-3-(dimethyl-amino)-propanone hydrochloride was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05238939 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-7733f4d5f36f421fa766662d35eb3f40 |
| Source note | uspto-grants-1993_08 |