Hydrochloric Acid → HCID 23179855, compound

HRID 2255139Notes

Reaction equation

HRID 2255139 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](C(=O)C)=[CH:4][CH:3]=1.[ClH:11].[CH3:12][NH:13][CH3:14].[CH2:15]=O.Cl.[CH2:18]([OH:20])[CH3:19]>>[ClH:11].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:19][C:18](=[O:20])[CH2:12][N:13]([CH3:15])[CH3:14])=[CH:4][CH:3]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 712FormaldehydeHCID 98284'-FluoroacetophenoneHCID 10473Dimethylamine, hydrochloride

Product 1

HCID 23179855HCID 23179855, compoundYield 82%

Procedure

A mixture of 54 g of 1-(4-fluorophenyl)ethanone, 39,1 g of dimethylamine hydrochloride, 14,4 g of paraformaldehyde, and 10 ml of 36% hydrochloric acid was refluxed for 2 h in 500 ml of ethanol. The ethanol was evaporated and ethyl acetate was added, after which 79 g (82%) of 1-(4-fluorophenyl)-3-(dimethyl-amino)-propanone hydrochloride was obtained.

Workup

  1. customThe ethanol was evaporated
  2. additionethyl acetate was added

Sources & evidence

ORD record
ord-7733f4d5f36f421fa766662d35eb3f40
Source dataset
uspto-grants-1993_08
Patent number
US05238939

Reaction notes

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