Sodium Hydroxide → HCID 15292775, compound

HRID 2255164Notes

Reaction equation

HRID 2255164 reaction equation
C([O:3][C:4]([C:6]1[NH:11][C:10](=[O:12])[C:9]([CH2:13][CH:14]([CH3:16])[CH3:15])=[N+:8]([O-:17])[C:7]=1[O:18][CH3:19])=[O:5])C.[OH-].[Na+]>CO>[CH2:13]([C:9]1[C:10](=[O:12])[NH:11][C:6]([C:4]([OH:5])=[O:3])=[C:7]([O:18][CH3:19])[N+:8]=1[O-:17])[CH:14]([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19378763HCID 19378763, compound

Product 1

HCID 15292775HCID 15292775, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 932 mg of 6-ethoxycarbonyl-3-isobutyl-5-methoxy-1,2-dihydropyrazine-2-one 4-oxide dissolved in 21 ml of methanol and 10 ml of an aqueous 1N sodium hydroxide solution was stirred for 4 hours at room temperature. The reaction mixture was made acidic with 10% hdyrochloric acid. The resulting crystals were collected by filtration and dissolved in chloroform-methanol. The solvent was removed by evaporation to obtain 830 mg of 3-isobutyl-5-methoxy-1,2-dihydropyrazin-2-one-6-carboxylic acid 4-oxide (Compound B-34) as a white solid.

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. dissolutiondissolved in chloroform-methanol
  3. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-5eba75157a314bab971de4264dbe2ce1
Source dataset
uspto-grants-1993_08
Patent number
US05238938

Reaction notes

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