Sodium Hydroxide → HCID 15292775, compound

Participants

Reaction Steps

A solution of 932 mg of 6-ethoxycarbonyl-3-isobutyl-5-methoxy-1,2-dihydropyrazine-2-one 4-oxide dissolved in 21 ml of methanol and 10 ml of an aqueous 1N sodium hydroxide solution was stirred for 4 hours at room temperature. The reaction mixture was made acidic with 10% hdyrochloric acid. The resulting crystals were collected by filtration and dissolved in chloroform-methanol. The solvent was removed by evaporation to obtain 830 mg of 3-isobutyl-5-methoxy-1,2-dihydropyrazin-2-one-6-carboxylic acid 4-oxide (Compound B-34) as a white solid.

Provenance & Evidence