反应详情

To a 250 ml round bottomed flask was added 5.00 g (22.21 mmol) of the 6-bromotetralone afforded above in Step B; 70 ml of dry toluene and 3.1 g (3.7 ml) of pyrrolidine. The flask was equipped with a Dean-Stark trap, a condenser, a nitrogen inlet tube and a magnetic stirrer and the reaction refluxed for four hours. The solvent was evaporated under vacuum to afford 6.02 g (97.4%) of the subtitle compound as a brown crystalline material which was used without further purification.

1. customafforded above in Step B
2. customThe flask was equipped with a Dean-Stark trap, a condenser, a nitrogen inlet tube and a magnetic stirrer
3. temperaturethe reaction refluxed for four hours
4. customThe solvent was evaporated under vacuum