Methyl iodide → HCID 57200436, compound

HRID 2255262Notes

Reaction equation

HRID 2255262 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:6][CH2:5]2.[CH3:17]I>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:17])=[C:7]([N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:6][CH2:5]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 10465943HCID 10465943, compound

Product 1

HCID 57200436HCID 57200436, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 6-fluoro-2-pyrrolidinyl-3,4-dihydronaphthalene (13 g; 60.8 mmol) in 200 ml of dry tetrahydrofuran (THF) was added methyliodide (30 ml; 482 mmol) and the mixture was refluxed for 2 hours. The reaction mixture was allowed to cool with stirring while crystallization took place. The solids were collected by filtration to afford the subtitle compound.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureto cool
  3. filtrationThe solids were collected by filtration

Sources & evidence

ORD record
ord-1808cb3e0cdc4c7e83f24e508f494536
Source dataset
uspto-grants-1993_08
Patent number
US05239075

Reaction notes

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