Hydrochloric Acid → 5-Chloro-6-ethylsulfanyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 225528Notes

Reaction equation

HRID 225528 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([S:18][CH2:19][CH3:20])=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[ClH:17].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[S:18][CH2:19][CH3:20])[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577534485-Chloro-6-ethylsulfanyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688221195-Chloro-6-ethylsulfanyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-Chloro-6-ethylsulfanyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and HCl. Off-white solid. MS (m/e): 216.2 ({37Cl}M+H+, 42%), 214.2 ({35Cl}M+H+, 100%).

Sources & evidence

ORD record
ord-b1cb9c01a5b24898b4ede2d443d52b35
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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