反应详情

A mixture comprising 150 mg (0.911 mmole) of 4-chloro-1,5-naphthyridine and 1.00 g of 4-fluorophenol was heated at 160° C. After one hour, the mixture was cooled and dissolved in ethyl acetate and 2N sodium hydroxide. The organic layer was washed twice with base to remove excess 4-fluorophenol. The organic layer was then dried with magnesium sulfate and concentrated, producing an oil that slowly crystallized. This product was recrystallized in heptane, giving 103 mg of the title product. MP 122°-124° C. Yield 47%.

1. temperaturethe mixture was cooled
2. washThe organic layer was washed twice with base
3. customto remove excess 4-fluorophenol
4. dry with materialThe organic layer was then dried with magnesium sulfate
5. concentrationconcentrated
6. customproducing an oil that
7. customslowly crystallized
8. customThis product was recrystallized in heptane