참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 4-Chloro-1,5-naphthyridine | HCID 596262 | — |
| 반응물 | 2-(4-Tert-butylphenyl)ethan-1-amine | HCID 2735689 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-[2-[4-(t-butyl)phenyl]ethyl]-1,5-naphthyridin-4-amine | HCID 19737873 | 30% |
반응 단계
A mixture of 500 mg of 4-chloro-1,5-naphthyridine and 1.0 g of N-[2-[4-(t-butyl)phenyl]ethyl]amine was stirred at 130° C. for 30 minutes. Then a 50/50 mixture of ammonium hydroxide and water was added. The product was extracted into methylene chloride, which was then concentrated. The product was purified by HPLC (silica gel, 20% ethyl acetate/80% pentane). The fractions containing the major product were collected and concentrated giving 0.277 mg of the title product as an oil. Yield 30%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05240916 |
|---|
| 출처 데이터셋 | uspto-grants-1993_08 |
|---|
| ORD ID | ord-6182ed75fcdf4aa9a3fa262de0b2afc2 |
|---|
| 출처 메모 | uspto-grants-1993_08 |
|---|
