反应详情

温度

130 °C

A mixture of 500 mg of 4-chloro-1,5-naphthyridine and 1.0 g of N-[2-[4-(t-butyl)phenyl]ethyl]amine was stirred at 130° C. for 30 minutes. Then a 50/50 mixture of ammonium hydroxide and water was added. The product was extracted into methylene chloride, which was then concentrated. The product was purified by HPLC (silica gel, 20% ethyl acetate/80% pentane). The fractions containing the major product were collected and concentrated giving 0.277 mg of the title product as an oil. Yield 30%.

1. additionwas added
2. extractionThe product was extracted into methylene chloride, which
3. concentrationwas then concentrated
4. customThe product was purified by HPLC (silica gel, 20% ethyl acetate/80% pentane)
5. additionThe fractions containing the major product
6. customwere collected
7. concentrationconcentrated