Hydrochloric Acid → 5-Pyrrolidin-1-yl-2,3-dihydro-1H-isoindole

HRID 225537Notes

Reaction equation

HRID 225537 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[N:17]1([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577534845-Pyrrolidin-1-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 577533975-Pyrrolidin-1-yl-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A3(e) from 5-Pyrrolidin-1-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and HCl. Brown oil. MS (m/e): 189.6 (M+H+, 100%).

Sources & evidence

ORD record
ord-a0be2a526e324f6990aa76ef6ac94677
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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