3-Pyridinecarboxaldehyde → HCID 4052667, compound

HRID 2255383Notes

Reaction equation

HRID 2255383 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][C:7]#[N:8])=[CH:4][CH:3]=1.[N:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH:17]=O)[CH:12]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](=[CH:17][C:13]2[CH:12]=[N:11][CH:16]=[CH:15][CH:14]=2)[C:7]#[N:8])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 103713-PyridinecarboxaldehydeHCID 14798Sodium HydroxideHCID 2415824-Chlorobenzyl cyanide

Product 1

HCID 4052667HCID 4052667, compound

Procedure

This intermediate (157 g.) was prepared using the procedure described in Example 12a except using 110.0 g. (0.738 mole) of 4-chlorobenzyl cyanide, 81.0 g. (0.74 mole) of 3-pyridinecarboxaldehyde, and 40 ml. of 10% aqueous sodium hydroxide.

Workup

  1. customThis intermediate (157 g.) was prepared

Sources & evidence

ORD record
ord-7f44529653aa4c6586b8f2a67e97fc1b
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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