Sodium Hydroxide → HCID 19738030, compound

HRID 2255390Notes

Reaction equation

HRID 2255390 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#[N:6].Cl.Cl[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.[OH-].[Na+]>CS(C)=O>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[CH:4]([CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[C:5]#[N:6]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 79624N-(3-chloropropyl)piperidine hydrochlorideHCID 805662,4-Dichlorophenylacetonitrile

Product 1

HCID 19738030HCID 19738030, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

This intermediate (10 g.) was prepared using the procedure described in Example 14a except using 10.0 g. (0.054 mole) of 2,4-dichlorobenzyl cyanide, 11.0 g. (0.054 mole) of 1-(3-chloropropyl)piperidine hydrochloride, 11.0 g. (0.135 mole) of 50% aqueous sodium hydroxide, and 50 ml. of DMSO.

Workup

  1. customThis intermediate (10 g.) was prepared

Sources & evidence

ORD record
ord-d28103a3ffe14259b9ccec03afb7b366
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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