Sodium Hydroxide → 1-[2-Cyano-2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propyl]-1,2,4-triazole

HRID 2255393Notes

Reaction equation

HRID 2255393 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([CH3:19])[CH2:14]1)[C:10]#[N:11].Cl[CH2:21][N:22]1[CH:26]=[N:25][CH:24]=[N:23]1.[OH-].[Na+]>CS(C)=O>[C:10]([C:9]([C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])([CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([CH3:19])[CH2:14]1)[CH2:21][N:22]1[CH:26]=[N:25][CH:24]=[N:23]1)#[N:11]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 37438821-Chloromethyl-1H-1,2,4-triazoleHCID 197380232-(2,4-Dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile

Product 1

HCID 197380181-[2-Cyano-2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propyl]-1,2,4-triazole

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

This compound (1.8 g.) was prepared using the procedure described in Example 9b except using 3.0 g. (0.010 mole) of 2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile, 1.7 g. (0.011 mole) of 1-(chloromethyl)-1,2,4-triazole, 2.0 g. (0.025 mole) of 50% aqueous sodium hydroxide, and 30 ml. of DMSO yielding a white solid, melting point 125°-126° C.

Workup

  1. customThis compound (1.8 g.) was prepared

Sources & evidence

ORD record
ord-240f84cc62f0496da06984bb07f93015
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

Loading…