HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-[2-Cyano-2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propyl]-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Chloromethyl-1H-1,2,4-triazole | HCID 3743882 | — |
| Reactant | 2-(2,4-Dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile | HCID 19738023 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-[2-Cyano-2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propyl]-1,2,4-triazole | HCID 19738018 | — |
Reaction Steps
This compound (1.8 g.) was prepared using the procedure described in Example 9b except using 3.0 g. (0.010 mole) of 2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile, 1.7 g. (0.011 mole) of 1-(chloromethyl)-1,2,4-triazole, 2.0 g. (0.025 mole) of 50% aqueous sodium hydroxide, and 30 ml. of DMSO yielding a white solid, melting point 125°-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05240925 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-240f84cc62f0496da06984bb07f93015 |
| Source note | uspto-grants-1993_08 |