Glycine ethyl ester → N-(2-amino-3,4-dioxo-1-cyclobutenyl)glycine ethyl ester

HRID 2255463Notes

Reaction equation

HRID 2255463 reaction equation
[NH2:1][C:2]1[C:3](=O)[C:4](=[O:9])[C:5]=1[O:6]CC.[NH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH2:16]([O:15][C:13](=[O:14])[CH2:12][NH:11][C:3]1[C:4](=[O:9])[C:5](=[O:6])[C:2]=1[NH2:1])[CH3:17]

Participants

3

Reactant 2

HCID 12176Glycine ethyl esterHCID 151463363-Amino-4-ethoxycyclobut-3-ene-1,2-dione

Product 1

HCID 10035618N-(2-amino-3,4-dioxo-1-cyclobutenyl)glycine ethyl ester

Procedure

In the same manner, condensing stoichiometric amounts of 3-amino-4-ethoxy-3-cyclobutene-1,2-dione with ethyl glycinate produces N-(2-amino-3,4-dioxo-1-cyclobutenyl)glycine ethyl ester, m.p. 231°-233° C.

Sources & evidence

ORD record
ord-13890d683aef49c5a1c7d4741b6aa157
Source dataset
uspto-grants-1993_08
Patent number
US05240946

Reaction notes

Loading…