反应详情

温度

110 °C

Concentrated sulfuric acid (10 ml) was added to 1.0 g of 5-cyano-3,4-dichloroisothiazole. When heated at 110° C. for 20 minutes, the isothiazole compound was dissolved completely. The reaction mixture was cooled under ice cooling, and precipitated crystals were collected by filtration. The crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water.

1. temperatureThe reaction mixture was cooled under ice cooling
2. customprecipitated crystals
3. filtrationwere collected by filtration
4. customThe crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water