HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2255489Generated: October 29, 2026
Sulfuric Acid → 3,4-Dichloro-5-isothiazolecarboxylic acid amide
https://huagongshe.com/reaction/2255489
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isothiazole | HCID 67515 | — |
| Reactant | Dichloro-1,2-thiazole-5-carbonitrile | HCID 19738264 | — |
| Product | 3,4-Dichloro-5-isothiazolecarboxylic acid amide | HCID 11333067 | — |
Reaction Steps
Concentrated sulfuric acid (10 ml) was added to 1.0 g of 5-cyano-3,4-dichloroisothiazole. When heated at 110° C. for 20 minutes, the isothiazole compound was dissolved completely. The reaction mixture was cooled under ice cooling, and precipitated crystals were collected by filtration. The crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05240951 |
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| Source dataset | uspto-grants-1993_08 |
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| ORD ID | ord-d7ac6bbb142a47bb9ad3c6bbee0a4550 |
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| Source note | uspto-grants-1993_08 |
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