Isopropylamine → HCID 19738254, compound

Participants

Reaction Steps

In 10 ml of dry tetrahydrofuran, 1.0 g of the 3,4-dichloro-5-isothiazolecarboxylic acid obtained in Example 2 was dissolved. While the resultant mixture was stirred at room temperature, a solution of 0.30 g of isopropylamine in 5 ml of dry tetrahydrofuran was added dropwise. White crystals were formed concurrently with the dropwise addition. After the resulting mixture was stirred further at room temperature for 30 minutes, the crystals were collected by filtration and then washed with a small amount of dry tetrahydrofuran. The crystals were dried at 40° C. for 30 minutes under reduced pressure, whereby 1.10 g of the title compound were obtained (yield: 85%).

Provenance & Evidence