Isopropylamine → HCID 19738254, compound

HRID 2255492Notes

Reaction equation

HRID 2255492 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]([OH:10])=[O:9])[S:4][N:3]=1.[CH:11]([NH2:14])([CH3:13])[CH3:12]>O1CCCC1>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]([O-:10])=[O:9])[S:4][N:3]=1.[CH:11]([NH3+:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 498373,4-Dichloro-5-isothiazolecarboxylic acid

Product 1

HCID 19738254HCID 19738254, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In 10 ml of dry tetrahydrofuran, 1.0 g of the 3,4-dichloro-5-isothiazolecarboxylic acid obtained in Example 2 was dissolved. While the resultant mixture was stirred at room temperature, a solution of 0.30 g of isopropylamine in 5 ml of dry tetrahydrofuran was added dropwise. White crystals were formed concurrently with the dropwise addition. After the resulting mixture was stirred further at room temperature for 30 minutes, the crystals were collected by filtration and then washed with a small amount of dry tetrahydrofuran. The crystals were dried at 40° C. for 30 minutes under reduced pressure, whereby 1.10 g of the title compound were obtained (yield: 85%).

Workup

  1. customWhite crystals were formed concurrently with the dropwise addition
  2. filtrationthe crystals were collected by filtration
  3. washwashed with a small amount of dry tetrahydrofuran
  4. customThe crystals were dried at 40° C. for 30 minutes under reduced pressure

Sources & evidence

ORD record
ord-9d9a19c7efc643af895f3ad835cf444a
Source dataset
uspto-grants-1993_08
Patent number
US05240951

Reaction notes

Loading…