Phenol → HCID 19385744, compound

HRID 2255584Notes

Reaction equation

HRID 2255584 reaction equation
C([O-])([O-])=O.[K+].[K+].CC(C)=O.C1(O)C=CC=CC=1.[OH:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=1[C:26](=[O:28])[CH3:27].Br[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[CH2:36][C:37]([O:39][CH3:40])=[O:38]>>[C:26]([C:20]1[CH:21]=[C:22]([CH3:25])[CH:23]=[CH:24][C:19]=1[O:18][CH:36]([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:30]=1)[C:37]([O:39][CH3:40])=[O:38])(=[O:28])[CH3:27]

Participants

5

Reactant 4

HCID 996PhenolHCID 150682-Hydroxy-5-methylacetophenoneHCID 8063364Methyl 2-(2-bromophenyl)acetateHCID 86600397Acetone potassium carbonate

Product 1

HCID 19385744HCID 19385744, compoundYield 63%

Procedure

Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 1.00 g (6.67 mmol) of 2'-hydroxy-5'-methylacetophenone was alkylated with 1.68 g (7.34 mmol) of methyl 2-bromophenylacetate to afford 1.25 g (63%) of the title compound.

Sources & evidence

ORD record
ord-71c7bd7b93774bdbad846a91b869a246
Source dataset
uspto-grants-1993_08
Patent number
US05240938

Reaction notes

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