HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzyl Alcohol → Methyl 2-(4-hydroxymethylphenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzyl Alcohol | HCID 125 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | Acetone potassium carbonate | HCID 86600397 | — |
| Product | Methyl 2-(4-hydroxymethylphenoxy)acetate | HCID 690034 | 48% |
Reaction Steps
Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 8.00 g (64.5 mmol) of 4-hydroxybenzyl alcohol was alkylated with 11.84 g (77.4 mmol) of methyl bromoacetate to afford 6.00 g (48%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05240938 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-2947d75886eb49318778e339e311c285 |
| Source note | uspto-grants-1993_08 |