反应详情

To a solution of 0.520 g (1.30 mmol) of the product of Step C dissolved in 3 mL of anhydrous THF was added 1.3 mL (1.3 mmol) of a 1N solution of tetra-n-butylammonium fluoride in THF and the mixture was stirred at room temperature 1.5 hours. The mixture was then concentrated in vacuo and the residue was purified on a silica gel flash chromatography column eluted with 70% ethyl acetate/hexane to afford 0.230 g (62%) of the title compound.

1. concentrationThe mixture was then concentrated in vacuo
2. customthe residue was purified on a silica gel flash chromatography column
3. washeluted with 70% ethyl acetate/hexane