Hydrochloric Acid → 5-(5-Methyl-thiophen-3-yl)-2,3-dihydro-1H-isoindole

HRID 225563Notes

Reaction equation

HRID 225563 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH:21]=[C:20]([CH3:22])[S:19][CH:18]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:22][C:20]1[S:19][CH:18]=[C:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH:21]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577534645-(5-Methyl-thiophen-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 577535495-(5-Methyl-thiophen-3-yl)-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A3(e) from 5-(5-Methyl-thiophen-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Light yellow solid. MS (m/e): 216.1 ([M+H]+, 100%)

Sources & evidence

ORD record
ord-0aa742015e224035958dfe942c811014
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

Loading…