HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → ethyl (2S*,3R*)-3-(t-butyldimethylsilyloxy)-2-(4-methoxybenzylaminomethyl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | ethyl 2-[(1R)-1-(t-butyldimethylsilyloxy)ethyl]acrylate | HCID 11108029 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | ethyl (2S*,3R*)-3-(t-butyldimethylsilyloxy)-2-(4-methoxybenzylaminomethyl)butanoate | HCID 57031907 | 109.5% |
Reaction Steps
To a solution of ethyl 2-[(1R)-1-(t-butyldimethylsilyloxy)ethyl]acrylate (15 g) in methanol (300 ml) was added 4-methoxybenzylamine (8.05 g) at room temperature. After stirring for 2 days, the solvent was removed by evaporation to give crude ethyl (2S,3R)-3-(t-butyldimethylsilyloxy)-2-(4-methoxybenzylaminomethyl)butanoate (25.14 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05241064 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-24f5b77d1929463b99f39f7eba3896d4 |
| Source note | uspto-grants-1993_08 |