HRID2255665

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75452

4-Methoxybenzylamine

C8H11NO

结构：C=C(C(=O)OCC)[C@@H](C)O[Si](C)(C)C(C)(C)C

HCID11108029

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@@H](CNCc1ccc(OC)cc1)[C@@H](C)O[Si](C)(C)C(C)(C)C

HCID57031907

未命名化合物

收率 109.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of ethyl 2-[(1R)-1-(t-butyldimethylsilyloxy)ethyl]acrylate (15 g) in methanol (300 ml) was added 4-methoxybenzylamine (8.05 g) at room temperature. After stirring for 2 days, the solvent was removed by evaporation to give crude ethyl (2S,3R)-3-(t-butyldimethylsilyloxy)-2-(4-methoxybenzylaminomethyl)butanoate (25.14 g).

WORKUP

后处理

customthe solvent was removed by evaporation