Hydrochloric Acid → 5-Thiazol-2-yl-2,3-dihydro-1H-isoindole

HRID 225567Notes

Reaction equation

HRID 225567 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[S:18][CH:19]=[CH:20][N:21]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[S:18]1[CH:19]=[CH:20][N:21]=[C:17]1[C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577534895-Thiazol-2-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 577537265-Thiazol-2-yl-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A3(e) from 5-Thiazol-2-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Yellow gum. MS (m/e): 202.8 ([M+H]+, 100%)

Sources & evidence

ORD record
ord-41c7f31e143f40d08171111c0b1aa56e
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

Loading…