HCID 19100947, compound → HCID 15070025, compound

HRID 2255692Notes

Reaction equation

HRID 2255692 reaction equation
[CH3:1][CH:2]1[CH2:9][CH:8]2[CH:4]([CH2:5][N:6](C(OCC)=O)[CH2:7]2)[NH:3]1>Cl>[CH3:1][CH:2]1[CH2:9][CH:8]2[CH:4]([CH2:5][NH:6][CH2:7]2)[NH:3]1

Participants

3

Reactant 1

HCID 19100947HCID 19100947, compound

Product 1

HCID 15070025HCID 15070025, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

17 g (85.7 mmol) of ethyl 3-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 50 ml of water, rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

Workup

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialThe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

Sources & evidence

ORD record
ord-d8080a2d741044e5900d40d1ffc6e448
Source dataset
uspto-grants-1993_08
Patent number
US05241076

Reaction notes

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