Octahydro-6-methyl-1-(phenylmethyl)pyrrolo[3,4-b]pyrrole → HCID 22924398, compound

HRID 2255715Notes

Reaction equation

HRID 2255715 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH:10]([CH3:16])[NH:11][CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:10]1[CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12][NH:11]1

Participants

4

Reactant 1

HCID 19100934Octahydro-6-methyl-1-(phenylmethyl)pyrrolo[3,4-b]pyrrole

Product 1

HCID 22924398HCID 22924398, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

7.8 g (36 mmol) of 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated at 100° C. and 100 bar on 2 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled. The distillate crystallizes.

Workup

  1. customare hydrogenated at 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-85460e61b24e4165955d61e1cc285559
Source dataset
uspto-grants-1993_08
Patent number
US05241076

Reaction notes

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