2-Methoxyethanol → 5-(2-Methoxy-ethoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 225580Notes

Reaction equation

HRID 225580 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:18][O:19][CH2:20][CH2:21][OH:22]>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:22][CH2:21][CH2:20][O:19][CH3:18])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577535595-(2-Methoxy-ethoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to Example A6(a) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and 2-methoxyethanol. White solid. MS (m/e): 237.9 ([M+H−Me2C═CH2]+, 100%)

Sources & evidence

ORD record
ord-f5013b1dea8f4c2e992c87e8ea69f1df
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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