Hydrochloric Acid → 1-(2,3-Dihydro-1H-isoindol-5-yl)-pyrrolidin-2-one hydrochloride

HRID 225583Notes

Reaction equation

HRID 225583 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:21][CH2:20][CH2:19][C:18]3=[O:22])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:23]>>[ClH:23].[CH2:9]1[C:10]2[C:15](=[CH:14][C:13]([N:17]3[CH2:21][CH2:20][CH2:19][C:18]3=[O:22])=[CH:12][CH:11]=2)[CH2:16][NH:8]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577535145-(2-Oxo-pyrrolidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688240821-(2,3-Dihydro-1H-isoindol-5-yl)-pyrrolidin-2-one hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-(2-oxo-pyrrolidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Off-white solid. MS (m/e): 203.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-f9d9778605b248f6bbaf571266c49ee1
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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