HCID 22375350, compound → HCID 22407312, compound

HRID 2255888Notes

Reaction equation

HRID 2255888 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:11][N:10]=2)=[CH:4][C:3]=1[N:20]1[C:25](=[O:26])[N:24]([CH3:27])[C:23](=[O:28])[N:22]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:21]1=[O:37]>FC(F)(F)C(O)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:18])([F:19])[F:17])=[CH:11][N:10]=2)=[CH:4][C:3]=1[N:20]1[C:25](=[O:26])[N:24]([CH3:27])[C:23](=[O:28])[N:22]([CH2:29][C:30]([OH:32])=[O:31])[C:21]1=[O:37]

Participants

3

Reactant 1

HCID 22375350HCID 22375350, compound

Product 1

HCID 22407312HCID 22407312, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 3-{2-bromo-5-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]oxy}phenyl}tetrahydro-5-methyl-2,4,6-trioxo-s-triazine-1(2H)-acetate (7.00 g, 0.012 mol) in trifluoroacetic acid (40 mL) is refluxed for 2.5 hours, cooled to room temperature and concentrated in vacuo to give the title product which is identified by 1HNMR spectral analysis.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-d103dfe16b304ecbb4109116c0110112
Source dataset
uspto-grants-1997_08
Patent number
US05654256

Reaction notes

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