Hydrochloric Acid → HCID 68822803, compound

HRID 225589Notes

Reaction equation

HRID 225589 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:22][CH2:21][C:20]([F:24])([F:23])[CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:25]>>[ClH:25].[F:24][C:20]1([F:23])[CH2:21][CH2:22][N:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57753513HCID 57753513, compound

Product 1

HCID 68822803HCID 68822803, compound

Procedure

Prepared in analogy to Example A3(e) from 5-(4,4-difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Light yellow solid. MS (m/e): 239.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-2dd74b8e35284d008f12b9dd43427d71
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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