Hydrochloric Acid → 5-Ethyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 225595Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:19]([F:22])([F:21])[F:20])=[C:13]([CH2:17][CH3:18])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:23]>>[ClH:23].[CH2:17]([C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[C:19]([F:22])([F:20])[F:21])[CH2:9][NH:8][CH2:16]2)[CH3:18]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 577535725-Ethyl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688242905-Ethyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-ethyl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. White solid. MS (m/e): 216.4 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-e42e9dd3b1044402b3eb2f39a226cabd
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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