Thionyl Chloride → 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride

HRID 2255973Notes

Reaction equation

HRID 2255973 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([C:12]([OH:14])=O)=[CH:9][CH:8]=1.S(Cl)([Cl:17])=O>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([C:12]([Cl:17])=[O:14])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 7364825-(Pyridin-2-yl)thiophene-2-carboxylic acid

Product 1

HCID 27761995-(2-Pyridinyl)-2-thiophenecarbonyl chloride

Procedure

A mixture of 1.0 g of 5-(2-pyridinyl)thiophene-2-carboxylic acid and 5 ml of thionyl chloride is refluxed for 2.5 hours. The mixture is concentrated to dryness under vacuum. Toluene is added (2 times) and the solvent removed under vacuum to give the product as an off-white solid.

Workup

  1. temperatureis refluxed for 2.5 hours
  2. concentrationThe mixture is concentrated to dryness under vacuum
  3. additionToluene is added (2 times)
  4. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-feac57a62c6a4aa3a8dac379c474acb1
Source dataset
uspto-grants-1997_08
Patent number
US05654297

Reaction notes

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