HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-(Pyridin-2-yl)thiophene-2-carboxylic acid | HCID 736482 | — |
| Product | 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride | HCID 2776199 | — |
Reaction Steps
A mixture of 1.0 g of 5-(2-pyridinyl)thiophene-2-carboxylic acid and 5 ml of thionyl chloride is refluxed for 2.5 hours. The mixture is concentrated to dryness under vacuum. Toluene is added (2 times) and the solvent removed under vacuum to give the product as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05654297 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-feac57a62c6a4aa3a8dac379c474acb1 |
| Source note | uspto-grants-1997_08 |