Hydrochloric Acid → 5-(Tetrahydro-pyran-4-yl)-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 225604Notes

Reaction equation

HRID 225604 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:23]([F:26])([F:25])[F:24])=[C:13]([CH:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:27]>>[ClH:27].[O:20]1[CH2:21][CH2:22][CH:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][C:12]=2[C:23]([F:26])([F:24])[F:25])[CH2:9][NH:8][CH2:16]3)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577532945-(Tetrahydro-pyran-4-yl)-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688612295-(Tetrahydro-pyran-4-yl)-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-(tetrahydro-pyran-4-yl)-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Yellow solid. MS (m/e): 272.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-a4c81c7fa8dd46cfa9d312207ccdc688
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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