2-(Piperidin-4-yl)pyridine → HCID 67713411, compound

HRID 2256069Notes

Reaction equation

HRID 2256069 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Cl:13][C:14]1[CH:15]=[C:16]([C@H:21]([CH2:33][CH:34]=O)[CH2:22][N:23]([CH3:32])[C:24](=[O:31])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:17]=[CH:18][C:19]=1[Cl:20]>>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]([C@H:21]([CH2:33][CH2:34][N:10]2[CH2:11][CH2:12][CH:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[CH2:8][CH2:9]2)[CH2:22][N:23]([CH3:32])[C:24](=[O:31])[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

3

Reactant 2

HCID 103747502-(Piperidin-4-yl)pyridineHCID 15381108(S)-N-[2-(3,4-Dichlorophenyl)-4-oxobutyl]-N-methylbenzamide

Product 1

HCID 67713411HCID 67713411, compound

Procedure

Using a procedure similar to that described in Example 1 (alternative preparation), except using 4-(2-pyridyl)piperidine and (S)-N-[2-(3,4-dichlorophenyl)-4-oxobutyl]-N-methylbenzamide, the title compound was prepared. Conversion to the hydrochloride salt Gave a white solid; mp 200°-202° C.; MS: 496; NMR: 2.14 (b, 8), 2.7 (s, 3), 3.4-3.9 (m, 8), 6.9-7.7 (m, 12), 8.16 (m, 1), 8.68 (m, 1), 10.4 (br, 1). Analysis for C28H31Cl2N3O·2.0 HCl·0.5 H2O: Calculated: C, 58.14; H, 5.92; N, 7.26 Found: C, 58.00; H, 5.90; N, 7.56.

Workup

  1. customthat described in Example 1 (alternative preparation)

Sources & evidence

ORD record
ord-bc59c83b6dcb418192b91604214e09b0
Source dataset
uspto-grants-1997_08
Patent number
US05654299

Reaction notes

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