2-(Piperidin-4-yl)pyridine → HCID 67713411, compound

Participants

Reaction Steps

Using a procedure similar to that described in Example 1 (alternative preparation), except using 4-(2-pyridyl)piperidine and (S)-N-[2-(3,4-dichlorophenyl)-4-oxobutyl]-N-methylbenzamide, the title compound was prepared. Conversion to the hydrochloride salt Gave a white solid; mp 200°-202° C.; MS: 496; NMR: 2.14 (b, 8), 2.7 (s, 3), 3.4-3.9 (m, 8), 6.9-7.7 (m, 12), 8.16 (m, 1), 8.68 (m, 1), 10.4 (br, 1). Analysis for C28H31Cl2N3O·2.0 HCl·0.5 H2O: Calculated: C, 58.14; H, 5.92; N, 7.26 Found: C, 58.00; H, 5.90; N, 7.56.

Provenance & Evidence