1-Boc-6-benzyloctahydropyrrolo[3,4-B]pyridine → 1-Boc-octahydropyrrolo(3,4-b)pyridine

HRID 2256082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2256082
C([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:20]([O:19][C:17]([N:11]1[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:16][NH:8][CH2:9][CH:10]12)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Komponenten

4

Edukt 1

HCID 190294191-Boc-6-benzyloctahydropyrrolo[3,4-B]pyridine

Produkt 1

HCID 225622021-Boc-octahydropyrrolo(3,4-b)pyridineAusbeute 96,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In 50 ml of ethanol was dissolved 2.86 g of 6-benzyl-1-t-butoxycarbonyloctahydropyrrolo[3.4-b]pyridine, and 500 mg of 5% palladium-on-carbon was added thereto. While the reaction vessel was heated by a tungsten lamp, hydrogenation was conducted under a pressurized hydrogen gas atmosphere of 4 kg/cm2 for 1.5 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to yield 1.98 g of the titled compound as an oily substance.

Aufarbeitung

  1. additionwas added
  2. temperatureWhile the reaction vessel was heated by a tungsten lamp
  3. customAfter completion of the reaction
  4. customthe catalyst was removed by filtration
  5. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-10c1ea16223e48f9bee65450198b27ba
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05654318

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