Trifluoroacetic acid → 5-(3-Methoxy-azetidin-1-yl)-2,3-Dihydro-1H-isoindole trifluoro-acetate

HRID 225618Notes

Reaction equation

HRID 225618 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:20][CH:19]([O:21][CH3:22])[CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[CH3:22][O:21][CH:19]1[CH2:20][N:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:18]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577533255-(3-Methoxy-azetidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester

Product 1

HCID 688223145-(3-Methoxy-azetidin-1-yl)-2,3-Dihydro-1H-isoindole trifluoro-acetate

Procedure

Prepared in analogy to Example A2(c) from 5-(3-methoxy-azetidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester and trifluoroacetic acid. Brown foam. MS (m/e): 205.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-75996286ff3342cbadbe9a3b8457cee3
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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