Sodium Hydroxide → HCID 19029742, compound

HRID 2256199Notes

Reaction equation

HRID 2256199 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH2:16][CH2:17][CH2:18][N:19]3[CH:23]=[CH:22][CH:21]=[C:20]3[C:24]([O:26]C)=[O:25])[C:4]=2[CH:3]=1.[OH-].[Na+]>C(O)C.CS(C)=O>[ClH:1].[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH2:16][CH2:17][CH2:18][N:19]3[CH:23]=[CH:22][CH:21]=[C:20]3[C:24]([OH:26])=[O:25])[C:4]=2[CH:3]=1

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 19029739HCID 19029739, compound

Product 2

HCID 313Hydrochloric AcidHCID 19029742HCID 19029742, compoundYield 188.1%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 702EthanolSolvent

Procedure

3.99 g (10 mmol) of the compound obtained in Example 11 are dissolved in 15 ml of ethanol and 7.5 ml of dimethyl sulfoxide. 0.8 g (20 mmol) of sodium hydroxide (in 1N solution) is added and the mixture is heated under reflux for 7 hours, with stirring. After acidification with a 1N hydrochloric acid solution and customary treatment of the organic phases, 3.62 g of the expected product are obtained.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 7 hours

Sources & evidence

ORD record
ord-1d93a4260cd141419656fa0e2031ae9a
Source dataset
uspto-grants-1997_08
Patent number
US05654323

Reaction notes

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