Trifluoroacetic acid → HCID 68824964, compound

HRID 225622Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:17]3[CH2:22][C@@H:21]4[CH2:23][C@H:18]3[CH2:19][O:20]4)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[C@H:21]12[CH2:23][C@H:18]([N:17]([C:13]3[CH:14]=[C:15]4[C:10](=[CH:11][CH:12]=3)[CH2:9][NH:8][CH2:16]4)[CH2:22]1)[CH2:19][O:20]2

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57753384HCID 57753384, compound

Product 1

HCID 68824964HCID 68824964, compound

Procedure

Prepared in analogy to Example A2(c) from (1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Orange oil. MS (m/e): 217.4 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-9918310412724541aa4396b0fec48fd2
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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