反应详情

A mixture of 1-[3-(3,4-dichlorophenyl)-5-hydroxy-1-oxopentyl]-1H-indole (4.25 g) and molecular sieves (4A, 2.75 g) in CH2Cl2 (40 mL) and was treated with TPAP (50 mg) and 4-methylmorpholine-N-oxide (2.75 mg) and stirred at room temperture for 2 hours. The reaction mixture was filtered through a pad of silica gel rinsed with EtOAc (100 mL) and concentrated under reduced pressure to yield an oil. Silica gel chromatography eluting with 50-75% EtOAc/Hexanes gave the desired title compound (930 mg).

1. filtrationThe reaction mixture was filtered through a pad of silica gel
2. washrinsed with EtOAc (100 mL)
3. concentrationconcentrated under reduced pressure
4. customto yield an oil
5. washSilica gel chromatography eluting with 50-75% EtOAc/Hexanes